Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 20/20 | 0.57 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.44 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.44 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3808726 | 0.94 | MAP2K1 (0.58) | MAP2K1MAP2K2MAP2K5EIF2AK1ABCB1 | |
| SCHEMBL3801305 | 0.88 | MAP2K1 (0.60) | MAP2K1MAP2K2MAP2K5EIF2AK1ABCB1 | |
| SCHEMBL13063785 | 0.87 | MAP2K1 (0.56) | MAP2K1MAP2K2MAP2K5EIF2AK1ABCB1 | |
| SCHEMBL13063610 | 0.87 | MAP2K1 (0.56) | MAP2K1MAP2K2MAP2K5EIF2AK1ABCB1 | |
| SCHEMBL3800551 | 0.87 | MAP2K1 (0.56) | MAP2K1MAP2K2MAP2K5EIF2AK1ABCB1 | |
| SCHEMBL13063553 | 0.87 | MAP2K1 (0.56) | MAP2K1MAP2K2MAP2K5EIF2AK1ABCB1 | |
| SCHEMBL13063537 | 0.87 | MAP2K1 (0.58) | MAP2K1MAP2K2MAP2K5EIF2AK1ABCB1 | |
| SCHEMBL13063858 | 0.87 | MAP2K1 (0.60) | MAP2K1MAP2K2MAP2K5EIF2AK1ABCB1 | |
| SCHEMBL13063599 | 0.87 | MAP2K1 (0.49) | MAP2K1MAP2K2MAP2K5EIF2AK1ABCB1 | |
| SCHEMBL13063566 | 0.87 | MAP2K1 (0.56) | MAP2K1MAP2K2MAP2K5EIF2AK1ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010145197-A1 | NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMDIES AS MEK INHIBITORS | CHEMIZON (BEIJING), LTD. (CN) | 2010-12-23 | — | — | WO | disclosed |