Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH2 | P48735 | 5/20 | 0.46 |
| ▸ | KIF11 | P52732 | 10/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL880139 | 0.85 | PTGIR (0.42) | KIF11 | |
| SCHEMBL13554399 | 0.81 | HTR2B (0.50) | HTTGRM5 | |
| SCHEMBL879693 | 0.80 | MAPKAPK2 (0.45) | — | |
| SCHEMBL851002 | 0.78 | RXFP1 (0.44) | — | |
| SCHEMBL10291452 | 0.74 | HTR2C (0.46) | HTT | |
| SCHEMBL879630 | 0.73 | TSHR (0.39) | — | |
| SCHEMBL10290859 | 0.73 | MAOB (0.43) | HTT | |
| Hydrochloric Acid SCHEMBL848811 | 0.72 | MAOB (0.42) | HTT | |
| Hydrochloric Acid SCHEMBL848812 | 0.72 | MAOB (0.42) | HTT | |
| SCHEMBL879731 | 0.71 | NISCH (0.45) | KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9487517-B2 | Spiroimidazolone derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2016-11-08 | — | — | US | disclosed |
| US-9169254-B2 | Spiroimidazolone derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2015-10-27 | — | — | US | disclosed |
| WO-2010126030-A1 | SPIROIMIDAZOLONE DERIVATIVE | 中外製薬株式会社 (JP) | 2010-11-04 | — | — | WO | disclosed |