Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1307413 | 0.87 | HDAC3 (0.56) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL1306638 | 0.87 | HDAC3 (0.72) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL1305567 | 0.83 | HDAC2 (0.73) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL1305474 | 0.83 | HDAC3 (0.65) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL1306240 | 0.83 | HDAC3 (0.65) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL1306606 | 0.81 | HDAC3 (0.63) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL1306749 | 0.79 | HDAC3 (0.56) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL1306197 | 0.76 | HDAC3 (0.49) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL1350893 | 0.76 | GAA (0.39) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL1306219 | 0.75 | SMN1; SMN2 (0.46) | HDAC3HDAC1HDAC2HDAC10HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053460-B2 | Chemoosensitizer for dug resistance tumors | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2011-11-08 | — | — | US | disclosed |
| US-20080207729-A1 | Chemoosensitizer for dug resistance tumors | SIGMA-TAU FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-08-28 | — | — | US | disclosed |
| EP-1891007-A1 | INDOLE DERIVATIVES HAVING ANTITUMOR ACTIVITY | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006131484-A1 | INDOLE DERIVATIVES HAVING ANTITUMOR ACTIVITY | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2006-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207729-A1 | Chemoosensitizer for dug resistance tumors | UTS2R, ABCC1, SLC11A2 | HDAC3 3639/4885HDAC1 2669/4885HDAC2 2819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.