Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | P2RY2 | P41231 | 7/20 | 0.42 |
| ▸ | P2RY4 | P51582 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.38 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.38 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.38 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.38 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | P2RY6 | Q15077 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16438958 | 0.90 | CYP3A4 (0.46) | POLA1LMNATHRBSMN1; SMN2HIF1A | |
| SCHEMBL19295878 | 0.90 | CYP3A4 (0.46) | POLA1LMNATHRBSMN1; SMN2HIF1A | |
| SCHEMBL21418772 | 0.90 | CYP3A4 (0.46) | POLA1LMNATHRBSMN1; SMN2HIF1A | |
| SCHEMBL19298159 | 0.90 | CYP3A4 (0.46) | POLA1LMNATHRBSMN1; SMN2HIF1A | |
| SCHEMBL19283199 | 0.90 | CYP3A4 (0.46) | POLA1LMNATHRBSMN1; SMN2HIF1A | |
| SCHEMBL16576283 | 0.90 | CYP3A4 (0.46) | POLA1LMNATHRBSMN1; SMN2HIF1A | |
| SCHEMBL19534468 | 0.90 | CYP3A4 (0.46) | POLA1LMNATHRBSMN1; SMN2HIF1A | |
| SCHEMBL21418788 | 0.90 | CYP3A4 (0.46) | POLA1LMNATHRBSMN1; SMN2HIF1A | |
| SCHEMBL13051686 | 0.87 | CYP3A4 (0.45) | POLA1LMNATHRBSMN1; SMN2HIF1A | |
| SCHEMBL19534548 | 0.87 | P2RY2 (0.52) | POLA1LMNATHRBSMN1; SMN2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010135569-A1 | N- [ (2 ' R) -2 ' -DEOXY-2 ' -FLUORO-2 ' -METHYL-P-PHENYL-5 ' -URIDYLYL] -L-ALANINE 1-METHYLETHYL ESTER AND PROCESS FOR ITS PRODUCTION | PHARMASSET, INC. (US) | 2010-11-25 | — | — | WO | disclosed |