Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31168086 | 0.84 | MRGPRX4 (0.44) | MRGPRX4CFTRPOLBABL1LMNA | |
| SCHEMBL12818154 | 0.81 | MRGPRX4 (0.46) | MRGPRX4HDAC3HDAC1HDAC2CFTR | |
| SCHEMBL3372772 | 0.78 | TDP1 (0.58) | MRGPRX4CFTRPOLBABL1EPHX2 | |
| SCHEMBL8612846 | 0.78 | MRGPRX4 (0.38) | PTGS1PTGS2MRGPRX4HDAC3HDAC1 | |
| SCHEMBL24436789 | 0.77 | CA12 (0.64) | MRGPRX4CFTRABL1LMNAEPHX2 | |
| SCHEMBL4039654 | 0.77 | CA12 (0.59) | LMNAALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL20644248 | 0.77 | CFTR (0.46) | MRGPRX4CFTRABL1EPHX2ALDH1A1 | |
| SCHEMBL31168096 | 0.77 | ABL1 (0.47) | MRGPRX4CFTRPOLBABL1PPARG | |
| SCHEMBL10487773 | 0.76 | FLT1 (0.57) | POLBABL1LMNAALDH1A1KDM4E | |
| SCHEMBL14547866 | 0.76 | GAA (0.58) | CFTRABL1PPARGPPARALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937659-B1 | CYCLIC N-[1,3,4]-THIADIAZOL-2-YL-BENZENE SULFONAMIDES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | SANOFI AVENTIS (FR) | 2010-11-10 | — | — | EP | disclosed |
| WO-2007039173-A1 | CYCLIC N-[1 ,3,4]-THIADIAZOL-2-YL-BENZENE SULFONAMIDES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | SANOFI-AVENTIS (DE) | 2007-04-12 | — | — | WO | disclosed |