Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 7/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 3/20 | 0.45 |
| ▸ | JAK1 | P23458 | 3/20 | 0.45 |
| ▸ | TYK2 | P29597 | 3/20 | 0.45 |
| ▸ | JAK3 | P52333 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | PRKACG | P22612 | 1/20 | 0.41 |
| ▸ | PRKACB | P22694 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1176308 | 0.84 | HAO1 (0.57) | PAK1HAO1 | |
| SCHEMBL12059754 | 0.83 | JAK1 (0.51) | PAK1HAO1JAK2JAK1TYK2 | |
| SCHEMBL13923941 | 0.78 | HAO1 (0.41) | PAK1HAO1JAK2JAK1TYK2 | |
| SCHEMBL13923940 | 0.78 | HAO1 (0.41) | PAK1HAO1JAK2JAK1TYK2 | |
| SCHEMBL13923946 | 0.78 | HAO1 (0.41) | PAK1HAO1JAK2JAK1TYK2 | |
| SCHEMBL2088249 | 0.77 | USP30 (0.40) | PAK1HAO1JAK2JAK1TYK2 | |
| SCHEMBL2087392 | 0.77 | USP30 (0.40) | PAK1HAO1JAK2JAK1TYK2 | |
| SCHEMBL2087537 | 0.77 | USP30 (0.40) | PAK1HAO1JAK2JAK1TYK2 | |
| SCHEMBL2087666 | 0.77 | DYRK1A (0.56) | PAK1DYRK1AMAPK1GSK3B | |
| SCHEMBL2087949 | 0.77 | DYRK1A (0.56) | PAK1DYRK1AMAPK1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742944-B1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARM CORP (US) | 2010-11-10 | — | — | EP | disclosed |