Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3375241 | 1.00 | CISD1 (0.33) | CISD1SRCCHEK1P2RX7 | |
| SCHEMBL3372749 | 1.00 | CISD1 (0.33) | CISD1SRCCHEK1P2RX7 | |
| SCHEMBL3375869 | 0.90 | PRKCQ (0.35) | — | |
| SCHEMBL14337685 | 0.90 | PRKCQ (0.35) | — | |
| SCHEMBL3375867 | 0.90 | PRKCQ (0.35) | — | |
| SCHEMBL3372531 | 0.84 | CISD1 (0.37) | CISD1 | |
| SCHEMBL3372536 | 0.84 | CISD1 (0.37) | CISD1 | |
| SCHEMBL3371516 | 0.84 | ABL1 (0.32) | SRC | |
| SCHEMBL3371513 | 0.84 | ABL1 (0.32) | SRC | |
| SCHEMBL14337687 | 0.84 | ABL1 (0.32) | SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869036-B1 | SUBSTITUTED 1,5-NAPHTHYRIDINE AZOLIDINONES AS CDK INHIBITORS | HOFFMANN LA ROCHE (CH) | 2010-11-03 | — | — | EP | disclosed |
| US-7304074-B2 | Substituted 1,5-naphthyridine azolinones | HOFFMANN-LA ROCHE INC. (US) | 2007-12-04 | — | — | US | disclosed |
| US-7304074-B2 | Substituted 1,5-naphthyridine azolinones | HOFFMANN-LA ROCHE INC. (US) | 2007-12-04 | — | — | US | disclosed |