Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13069471 | 0.84 | MAPT (0.54) | MAPTPOLBSMN1; SMN2TP53GAA | |
| SCHEMBL1024099 | 0.82 | POLB (0.68) | MAPTPOLBSMN1; SMN2TP53ACKR3 | |
| SCHEMBL1022664 | 0.80 | RXFP1 (0.61) | MAPTPOLBSMN1; SMN2TP53 | |
| SCHEMBL1020463 | 0.80 | MAPT (0.66) | MAPTPOLBSMN1; SMN2TP53THRB | |
| SCHEMBL1074464 | 0.74 | POLB (0.56) | MAPTPOLBSMN1; SMN2TP53ACKR3 | |
| SCHEMBL12707233 | 0.73 | MAPT (0.60) | MAPTPOLBSMN1; SMN2TP53ACKR3 | |
| SCHEMBL1021427 | 0.72 | POLB (0.74) | MAPTPOLBSMN1; SMN2TP53ACKR3 | |
| SCHEMBL1022484 | 0.70 | ACKR3 (0.67) | MAPTPOLBSMN1; SMN2TP53ACKR3 | |
| SCHEMBL1075232 | 0.69 | MAPT (0.65) | MAPTPOLBSMN1; SMN2TP53 | |
| SCHEMBL1020485 | 0.69 | MAPT (0.67) | MAPTPOLBSMN1; SMN2TP53THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954274-B1 | SUBSTITUTED QUINOLONES AND METHODS OF USE | CHEMOCENTRYX INC (US) | 2010-11-03 | — | — | EP | disclosed |