Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13069483 | 0.93 | GRM5 (1.00) | GRM5 | |
| SCHEMBL13068874 | 0.93 | GRM5 (0.87) | GRM5 | |
| SCHEMBL13683871 | 0.92 | GRM5 (0.85) | GRM5 | |
| SCHEMBL13684101 | 0.91 | GRM5 (1.00) | GRM5 | |
| SCHEMBL13683964 | 0.91 | GRM5 (0.83) | GRM5 | |
| SCHEMBL13683997 | 0.91 | GRM5 (1.00) | GRM5 | |
| SCHEMBL13068988 | 0.91 | GRM5 (1.00) | GRM5 | |
| SCHEMBL13683998 | 0.90 | GRM5 (1.00) | GRM5 | |
| SCHEMBL13683996 | 0.90 | GRM5 (1.00) | GRM5 | |
| SCHEMBL13683858 | 0.90 | GRM5 (0.81) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485093-B1 | DI-ARYL SUBSTITUTED TETRAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK SHARP & DOHME (US) | 2010-11-03 | — | — | EP | disclosed |
| US-7592337-B2 | Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5 | MERCK & CO., INC. (US) | 2009-09-22 | — | — | US | disclosed |
| US-7592337-B2 | Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5 | MERCK & CO., INC. (US) | 2009-09-22 | — | — | US | disclosed |