Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 18/20 | 0.55 |
| ▸ | WNT1 | P04628 | 12/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13069595 | 0.85 | GSK3B (0.58) | DYRK1AWNT1GSK3B | |
| SCHEMBL13069783 | 0.85 | DYRK1A (0.50) | DYRK1AWNT1GSK3BNPC1RAB9A | |
| SCHEMBL13069184 | 0.83 | DYRK1A (0.73) | DYRK1AWNT1GSK3B | |
| SCHEMBL13069629 | 0.82 | DYRK1A (0.48) | DYRK1AWNT1GSK3B | |
| SCHEMBL2086924 | 0.81 | DYRK1A (0.65) | DYRK1AWNT1GSK3BNPC1RAB9A | |
| SCHEMBL2086136 | 0.81 | DYRK1A (0.65) | DYRK1AWNT1GSK3BNPC1RAB9A | |
| SCHEMBL13069604 | 0.81 | DYRK1A (0.49) | DYRK1AWNT1GSK3B | |
| SCHEMBL2088141 | 0.81 | DYRK1A (0.70) | DYRK1AWNT1GSK3B | |
| SCHEMBL13069189 | 0.81 | DYRK1A (0.56) | DYRK1AWNT1GSK3B | |
| SCHEMBL4008423 | 0.80 | NPC1 (0.68) | DYRK1AWNT1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742944-B1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARM CORP (US) | 2010-11-10 | — | — | EP | disclosed |