Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 17/20 | 0.46 |
| ▸ | PPARD | Q03181 | 15/20 | 0.46 |
| ▸ | PPARA | Q07869 | 15/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | FABP1 | P07148 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3377036 | 0.92 | PPARG (0.47) | PPARGPPARDPPARACYP2C9CYP2C19 | |
| SCHEMBL3376896 | 0.90 | PPARD (0.53) | PPARGPPARDPPARA | |
| SCHEMBL3378784 | 0.87 | PPARA (0.47) | PPARGPPARDPPARACYP2C19MEN1 | |
| SCHEMBL3379784 | 0.86 | PPARD (0.46) | PPARGPPARDPPARACYP2C9CYP2C19 | |
| SCHEMBL3410208 | 0.86 | PPARA (0.48) | PPARGPPARDPPARAFABP1NR1H4 | |
| SCHEMBL3376214 | 0.86 | PPARG (0.51) | PPARGPPARDPPARAFABP1NR1H4 | |
| SCHEMBL3375295 | 0.85 | PPARA (0.47) | PPARGPPARDPPARA | |
| SCHEMBL3376815 | 0.84 | PPARA (0.53) | PPARGPPARDPPARA | |
| SCHEMBL13069652 | 0.83 | PPARA (0.48) | PPARGPPARDPPARACYP2C9CYP2C19 | |
| SCHEMBL13069472 | 0.82 | PPARA (0.53) | PPARGPPARDPPARACYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1796665-B1 | COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER LIPID DISORDERS | MERCK SHARP & DOHME (US) | 2010-11-17 | — | — | EP | disclosed |