Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 16/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14549250 | 0.93 | MAP2K1 (0.41) | MAP2K1KDRCYP3A4CHRNA7KCNH2 | |
| SCHEMBL391126 | 0.90 | MAP2K1 (0.55) | MAP2K1MAP2K2 | |
| SCHEMBL15468555 | 0.82 | MAP2K1 (0.44) | MAP2K1 | |
| SCHEMBL10195311 | 0.82 | MAP2K1 (0.54) | MAP2K1MAP2K2 | |
| SCHEMBL392179 | 0.82 | MAP2K1 (0.52) | MAP2K1MAP2K2 | |
| Hydrochloric Acid SCHEMBL388702 | 0.81 | MAP2K1 (0.53) | MAP2K1MAP2K2 | |
| Hydrochloric Acid SCHEMBL388701 | 0.81 | MAP2K1 (0.52) | MAP2K1MAP2K2 | |
| SCHEMBL13148417 | 0.77 | MAP2K1 (0.43) | MAP2K1CHRNA7KCNH2 | |
| SCHEMBL5623735 | 0.74 | MAP2K1 (0.52) | MAP2K1KDRCYP3A4MAP2K2CHRNA7 | |
| SCHEMBL391465 | 0.74 | MAP2K1 (0.51) | MAP2K1KDRMAP2K2FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251327-A2 | Heterocyclic inhibitors of MEK and methods of use thereof | Array Biopharma, Inc. (US) | 2010-11-17 | — | — | EP | disclosed |