Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 20/20 | 0.43 |
| ▸ | CNR2 | P34972 | 18/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14047820 | 0.83 | CNR1 (0.55) | CNR1CNR2GABRA1GABRB1GABRA5 | |
| SCHEMBL3396714 | 0.81 | CNR1 (0.48) | CNR1CNR2GABRA1GABRB1GABRA5 | |
| SCHEMBL13070406 | 0.80 | CNR1 (0.57) | CNR1CNR2GABRA1GABRB1GABRA5 | |
| SCHEMBL3395436 | 0.78 | CNR1 (0.44) | CNR1CNR2GABRA1GABRB1GABRA5 | |
| SCHEMBL3399771 | 0.78 | CNR1 (0.44) | CNR1CNR2GABRA1GABRB1GABRA5 | |
| SCHEMBL14047672 | 0.77 | CNR1 (0.73) | CNR1CNR2GABRA1GABRB1GABRA5 | |
| SCHEMBL14047670 | 0.76 | CNR1 (0.69) | CNR1CNR2GABRA1GABRB1GABRA5 | |
| SCHEMBL14046653 | 0.76 | CNR1 (0.73) | CNR1CNR2 | |
| SCHEMBL13070397 | 0.75 | CNR1 (0.69) | CNR1CNR2GABRA1GABRB1GABRA5 | |
| SCHEMBL14047673 | 0.74 | CNR1 (0.55) | CNR1CNR2GABRA1GABRB1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146997-B1 | SUBSTITUTED FURO[2,3-B]PYRIDINE DERIVATIVES AS CANNABINOID-1 RECEPTOR MODULATORS | MERCK SHARP & DOHME (US) | 2010-11-10 | — | — | EP | disclosed |
| WO-2008127585-A1 | SUBSTITUTED FURO[2,3-B]PYRIDINE DERIVATIVES AS CANNABINOID-1 RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2008-10-23 | — | — | WO | disclosed |