Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4793431 | 0.88 | — | — | |
| SCHEMBL12820010 | 0.88 | — | — | |
| SCHEMBL30251348 | 0.86 | MEN1 (0.42) | MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL10070322 | 0.86 | MEN1 (0.42) | MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL8300226 | 0.83 | NPC1 (0.45) | MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL12558063 | 0.83 | NPC1 (0.45) | MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL15672689 | 0.83 | SMN1; SMN2 (0.41) | MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL8296551 | 0.80 | — | — | |
| SCHEMBL13443785 | 0.80 | — | — | |
| SCHEMBL8276961 | 0.79 | KMT2A (0.48) | MEN1KMT2ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009142842-A9 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2010-11-25 | — | — | WO | disclosed |
| WO-2009142842-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-11-26 | — | — | WO | disclosed |