Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.46 |
| ▸ | BACE2 | Q9Y5Z0 | 12/20 | 0.46 |
| ▸ | CTSD | P07339 | 12/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13073618 | 0.95 | BACE1 (0.46) | BACE1BACE2CTSD | |
| SCHEMBL3509356 | 0.92 | BACE1 (0.45) | BACE1BACE2CTSD | |
| SCHEMBL3509355 | 0.92 | BACE1 (0.45) | BACE1BACE2CTSD | |
| SCHEMBL3509352 | 0.92 | BACE1 (0.45) | BACE1BACE2CTSD | |
| SCHEMBL3511286 | 0.91 | BACE1 (0.55) | BACE1BACE2CTSD | |
| SCHEMBL3511284 | 0.91 | BACE1 (0.55) | BACE1BACE2CTSD | |
| SCHEMBL3511280 | 0.91 | BACE1 (0.55) | BACE1BACE2CTSD | |
| SCHEMBL3512518 | 0.90 | BACE1 (0.49) | BACE1BACE2CTSD | |
| SCHEMBL3512515 | 0.90 | BACE1 (0.49) | BACE1BACE2CTSD | |
| SCHEMBL3512517 | 0.90 | BACE1 (0.49) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8299267-B2 | (3-hydroxy-4-amino-butan-2-yl) -3- (2-thiazol-2-yl-pyrrolidine-1-carbonyl) benzamide derivatives and related compounds as beta-secretase inhibitors for treating | COMENTIS, INC. (US) | 2012-10-30 | — | — | US | disclosed |
| US-20100286170-A1 | (3-HYDROXY-4-AMINO-BUTAN-2-YL) -3- (2-THIAZOL-2-YL-PYRROLIDINE-1-CARBONYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR TREATING | COMENTIS, INC | 2010-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286170-A1 | (3-HYDROXY-4-AMINO-BUTAN-2-YL) -3- (2-THIAZOL-2-YL-PYRROLIDINE-1-CARBONYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR TREATING | BACE1, BACE2, PSEN1 | BACE1 1/4885BACE2 2/4885CTSD 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.