Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK7 | Q13164 | 5/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | CES1 | P23141 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13075278 | 0.81 | MAPK7 (0.34) | MAPK7MAPK14HTTSMN1; SMN2HPGD | |
| SCHEMBL299928 | 0.81 | MAPK14 (0.40) | MAPK7MAPK14HTTHPGDCYP1A2 | |
| SCHEMBL298940 | 0.73 | MAPK14 (0.50) | MAPK7MAPK14HTTSMN1; SMN2HPGD | |
| SCHEMBL299876 | 0.64 | HDAC6 (0.38) | MAPK7MAPK14HTTLMNAPKM | |
| SCHEMBL299044 | 0.62 | MAPK14 (0.53) | MAPK7MAPK14HTTSMN1; SMN2HPGD | |
| SCHEMBL31162188 | 0.60 | MAPK8 (0.45) | HPGDALDH1A1NPSR1LMNA | |
| SCHEMBL606459 | 0.59 | MAPK14 (0.52) | MAPK7MAPK14HTTSMN1; SMN2HPGD | |
| SCHEMBL298880 | 0.58 | MAPK14 (0.58) | MAPK7MAPK14HTT | |
| SCHEMBL10042101 | 0.58 | MAPK14 (0.46) | MAPK7MAPK14HTTSMN1; SMN2HPGD | |
| SCHEMBL31162134 | 0.58 | MAPK8 (0.45) | MAPK14HPGDALDH1A1NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129208-A1 | P38 KINASE INHIBITING AGENTS | MERCK SHARP & DOHME CORP. (US) | 2010-11-11 | — | — | WO | disclosed |