Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.32 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.31 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL64667 | 0.76 | MAP4K4 (0.44) | MAP4K4TNIKRIPK1ACVRL1 | |
| SCHEMBL20820178 | 0.75 | MAP4K4 (0.47) | MAP4K4TNIKRIPK1ACVRL1 | |
| SCHEMBL15740086 | 0.73 | MAP4K4 (0.46) | MAP4K4TNIKRIPK1ACVRL1 | |
| SCHEMBL21137294 | 0.73 | MAP4K4 (0.42) | MAP4K4TNIKRIPK1ACVRL1 | |
| SCHEMBL13075167 | 0.72 | MAP4K4 (0.44) | MAP4K4TNIKRIPK1 | |
| SCHEMBL17238976 | 0.72 | MAP4K4 (0.44) | MAP4K4TNIKRIPK1 | |
| SCHEMBL57305 | 0.72 | MAP4K4 (0.44) | MAP4K4TNIKRIPK1 | |
| SCHEMBL21539427 | 0.71 | MAP4K4 (0.41) | MAP4K4TNIKRIPK1ACVRL1 | |
| SCHEMBL19402915 | 0.71 | MAP4K4 (0.41) | MAP4K4TNIKRIPK1ACVRL1 | |
| SCHEMBL12392887 | 0.71 | RET (0.41) | MAP4K4TNIKRIPK1ACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126960-A1 | PYRROLOTRIAZINE COMPOUNDS | LOCUS PHARMACEUTICALS, INC. (US) | 2010-11-04 | — | — | WO | disclosed |