Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.50 |
| ▸ | MTOR | P42345 | 3/20 | 0.50 |
| ▸ | SYK | P43405 | 6/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CCR4 | P51679 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | LYN | P07948 | 1/20 | 0.33 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13075772 | 0.85 | PIK3CA (0.47) | PIK3CAMTORSYKEGFRPDGFRB | |
| SCHEMBL13075775 | 0.71 | PIK3CA (0.47) | PIK3CAMTOREGFRPIK3CDPIK3CB | |
| SCHEMBL13076085 | 0.68 | PIK3CA (0.59) | PIK3CAMTORSYKPIK3CDPIK3CB | |
| SCHEMBL168764 | 0.67 | PIK3CA (1.00) | PIK3CAMTOREGFRPDGFRBKDR | |
| SCHEMBL763440 | 0.66 | SYK (0.60) | SYKKCNH2MAPK1ZAP70 | |
| SCHEMBL20850719 | 0.64 | RET (0.41) | PIK3CAMTORSYKEGFRPDGFRB | |
| SCHEMBL17916010 | 0.63 | EGFR (0.49) | PIK3CAMTORSYKEGFRPDGFRB | |
| SCHEMBL17060351 | 0.62 | DHODH (0.51) | PIK3CAMTORSYKEGFRPDGFRB | |
| SCHEMBL20850880 | 0.62 | RET (0.41) | PIK3CAMTORSYKEGFRPDGFRB | |
| SCHEMBL13075456 | 0.61 | PIK3CA (0.47) | PIK3CAMTOREGFRPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010126895-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC. (US) | 2010-11-04 | — | — | WO | disclosed |