Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 11/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL744930 | 0.91 | ABCB1 (0.65) | ABCB1SMN1; SMN2KDM4EMAPTLMNA | |
| SCHEMBL13075169 | 0.91 | ABCB1 (0.56) | ABCB1SMN1; SMN2KDM4EMAPTLMNA | |
| SCHEMBL20858994 | 0.90 | ABCB1 (0.58) | ABCB1SMN1; SMN2KDM4EMAPTLMNA | |
| SCHEMBL7027820 | 0.88 | ABCB1 (0.56) | ABCB1SMN1; SMN2KDM4EMAPTLMNA | |
| SCHEMBL20858971 | 0.84 | ABCB1 (0.56) | ABCB1ACHE | |
| SCHEMBL13075711 | 0.83 | MAPT (0.51) | ABCB1SMN1; SMN2KDM4EMAPTLMNA | |
| SCHEMBL7030120 | 0.82 | ABCB1 (0.67) | ABCB1 | |
| SCHEMBL743214 | 0.81 | ABCB1 (0.65) | ABCB1SMN1; SMN2KDM4EMAPTLMNA | |
| SCHEMBL744982 | 0.81 | ABCB1 (0.62) | ABCB1SMN1; SMN2KDM4EMAPTLMNA | |
| SCHEMBL746093 | 0.81 | ABCB1 (0.63) | ABCB1SMN1; SMN2KDM4EMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129858-A1 | COMPOUNDS AND COMPOSITIONS COMPRISING CDK INHIBITORS AND METHODS FOR THE TREATMENT OF CANCER | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2010-11-11 | — | — | WO | disclosed |