Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 3/20 | 0.57 |
| ▸ | KDM1A | O60341 | 5/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13075268 | 1.00 | GRIA4 (0.57) | GRIA4KDM1AMAOBADRA2AADRA2B | |
| SCHEMBL22754979 | 1.00 | GRIA4 (0.57) | GRIA4KDM1AMAOBADRA2AADRA2B | |
| SCHEMBL13452615 | 1.00 | GRIA4 (0.57) | GRIA4KDM1AMAOBADRA2AADRA2B | |
| SCHEMBL19493576 | 1.00 | GRIA4 (0.57) | GRIA4KDM1AMAOBADRA2AADRA2B | |
| SCHEMBL26721601 | 0.96 | GRIA4 (0.53) | GRIA4KDM1AMAOBADRA2AADRA2B | |
| SCHEMBL20833256 | 0.96 | GRIA4 (0.53) | GRIA4KDM1AMAOBADRA2AADRA2B | |
| SCHEMBL7046563 | 0.96 | GRIA4 (0.53) | GRIA4KDM1AMAOBADRA2AADRA2B | |
| SCHEMBL22260111 | 0.88 | KDM1A (0.53) | GRIA4KDM1AMAOBADRA2AHTR2C | |
| SCHEMBL736813 | 0.82 | GRIA4 (0.58) | GRIA4HTR2C | |
| SCHEMBL16748038 | 0.81 | KDM1A (0.42) | GRIA4KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010131145-A1 | CYCLOBUTENEDIONE DERIVATIVES | PFIZER LIMITED (GB) | 2010-11-18 | — | — | WO | disclosed |