Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 2/20 | 0.43 |
| ▸ | CCND1 | P24385 | 2/20 | 0.43 |
| ▸ | CCND3 | P30281 | 1/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.32 |
| ▸ | SCN1A | P35498 | 1/20 | 0.32 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.32 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.32 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL112968 | 0.79 | CDK4 (0.52) | CDK4CCND1CCND3CDK6JAK3 | |
| SCHEMBL13075594 | 0.75 | CDK4 (0.43) | CDK4CCND1CCND3CDK6 | |
| SCHEMBL111269 | 0.74 | CDK4 (0.49) | CDK4CCND1CCND3CDK6 | |
| SCHEMBL112506 | 0.71 | CDK4 (0.63) | CDK4CCND1CCND3CDK6 | |
| SCHEMBL110403 | 0.70 | CDK4 (0.62) | CDK4CCND1CCND3CDK6ATR | |
| SCHEMBL111573 | 0.69 | CDK4 (0.80) | CDK4CCND1CCND3CDK6 | |
| SCHEMBL111484 | 0.68 | CDK4 (0.62) | CDK4CCND1CCND3CDK6 | |
| SCHEMBL2143455 | 0.68 | CDK4 (0.51) | CDK4CCND1CCND3CDK6 | |
| SCHEMBL13076251 | 0.66 | CDK4 (0.48) | CDK4CCND1CCND3CDK6ATR | |
| SCHEMBL112177 | 0.64 | CDK4 (0.75) | CDK4CCND1CCND3CDK6MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125402-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES | NOVARTIS AG (CH) | 2010-11-04 | — | — | WO | disclosed |