Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 10/20 | 0.48 |
| ▸ | CSF1R | P07333 | 8/20 | 0.48 |
| ▸ | BLK | P51451 | 7/20 | 0.48 |
| ▸ | KDR | P35968 | 14/20 | 0.46 |
| ▸ | FLT3 | P36888 | 12/20 | 0.46 |
| ▸ | FLT1 | P17948 | 7/20 | 0.46 |
| ▸ | FLT4 | P35916 | 7/20 | 0.46 |
| ▸ | LYN | P07948 | 6/20 | 0.46 |
| ▸ | LCK | P06239 | 6/20 | 0.46 |
| ▸ | ABL1 | P00519 | 3/20 | 0.46 |
| ▸ | SRC | P12931 | 3/20 | 0.46 |
| ▸ | FYN | P06241 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.44 |
| ▸ | AURKA | O14965 | 3/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.44 |
| ▸ | RET | P07949 | 3/20 | 0.44 |
| ▸ | MET | P08581 | 3/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13041777 | 0.95 | KIT (0.49) | KITCSF1RBLKKDRFLT3 | |
| SCHEMBL13041771 | 0.88 | KDR (0.47) | KITCSF1RBLKKDRFLT3 | |
| SCHEMBL13041764 | 0.88 | KDR (0.51) | KITCSF1RBLKKDRFLT3 | |
| SCHEMBL13041778 | 0.87 | KIT (0.52) | KITCSF1RBLKKDRFLT3 | |
| SCHEMBL13041768 | 0.87 | CSF1R (0.52) | KITCSF1RBLKKDRFLT3 | |
| SCHEMBL13041758 | 0.86 | KDR (0.50) | KITCSF1RBLKKDRFLT3 | |
| SCHEMBL13041765 | 0.86 | KDR (0.61) | KITCSF1RBLKKDRFLT3 | |
| SCHEMBL13041774 | 0.86 | KIT (0.50) | KITCSF1RBLKKDRFLT3 | |
| SCHEMBL13041755 | 0.86 | CSF1R (0.53) | KITCSF1RBLKKDRFLT3 | |
| SCHEMBL13041781 | 0.86 | KIT (0.58) | KITCSF1RBLKKDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825114-B2 | Substituted aminopyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same | BAYER SCHERING PHARMA AG (DE) | 2010-11-02 | — | — | US | disclosed |
| US-20090018129-A1 | SUBSTITUTED AMINOPYRAZOLOPYRIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2009-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018129-A1 | SUBSTITUTED AMINOPYRAZOLOPYRIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME | KDR, TIE1, TEK | KIT 22/4885CSF1R 918/4885BLK 305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.