Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 2/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8446912 | 1.00 | CA1 (0.53) | CA1CA2CA7CYP1A2CYP2C9 | |
| SCHEMBL741043 | 0.88 | CA1 (0.55) | CA1CA2CA7CTSLCTSB | |
| SCHEMBL5564464 | 0.88 | CA1 (0.55) | CA1CA2CA7CTSLCTSB | |
| SCHEMBL10724727 | 0.88 | CA1 (0.55) | CA1CA2CA7CTSLCTSB | |
| SCHEMBL19618687 | 0.88 | CA1 (0.55) | CA1CA2CA7CTSLCTSB | |
| SCHEMBL10724721 | 0.88 | CA1 (0.55) | CA1CA2CA7CTSLCTSB | |
| SCHEMBL14385267 | 0.85 | CA1 (0.53) | CA1CA2CA7CTSLCTSB | |
| SCHEMBL10138729 | 0.84 | CA1 (0.46) | CA1CA2CA7CYP1A2CYP2C9 | |
| SCHEMBL13688686 | 0.84 | CA1 (0.46) | CA1CA2CA7CYP1A2CYP2C9 | |
| SCHEMBL6373993 | 0.84 | CYP1A2 (0.47) | CA1CA2CA7CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7829669-B2 | Catalytically active recombinant memapsin and methods of use thereof | OKLAHOMA MEDICAL RESEARCH FOUNDATION (US) | 2010-11-09 | — | — | US | disclosed |
| US-7678760-B2 | Inhibitors of Memapsin 2 and use thereof | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2010-03-16 | — | — | US | disclosed |
| US-20080112946-A1 | Catalytically active recombinant memapsin and methods of use thereof | OKLAHOMA MEDICAL RESEARCH FOUNDATION | 2008-05-15 | — | — | US | disclosed |
| US-20080021196-A1 | INHIBITORS OF MEMAPSIN 2 AND USE THEREOF | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2008-01-24 | — | — | US | disclosed |
| US-7244708-B2 | Inhibitors of memapsin 2 and use thereof | OKLAHOMA MEDICAL RESEARCH FOUNDATION (US) | 2007-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080112946-A1 | Catalytically active recombinant memapsin and methods of use thereof | ANPEP, PSEN2, APP | CA1 1903/4885CA2 2885/4885CA7 4124/4885 |
| US-20080021196-A1 | INHIBITORS OF MEMAPSIN 2 AND USE THEREOF | PSEN2, APP, ANPEP | CA1 2083/4885CA2 2733/4885CA7 4349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.