Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 2/20 | 0.65 |
| ▸ | HTR2A | P28223 | 2/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
| ▸ | BTK | Q06187 | 11/20 | 0.54 |
| ▸ | SYK | P43405 | 5/20 | 0.51 |
| ▸ | JAK3 | P52333 | 10/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13079878 | 0.88 | IRAK4 (0.53) | MERTKHTR2AHTR2CBTKSYK | |
| SCHEMBL13079729 | 0.86 | HTR2A (0.55) | MERTKHTR2AHTR2CBTKSYK | |
| SCHEMBL13048678 | 0.85 | HTR2A (0.52) | MERTKHTR2AHTR2CBTKSYK | |
| SCHEMBL13048677 | 0.84 | HTR2A (0.60) | MERTKHTR2AHTR2CBTKSYK | |
| SCHEMBL13079395 | 0.84 | HTR2A (0.63) | MERTKHTR2AHTR2CBTKSYK | |
| SCHEMBL12085425 | 0.83 | MERTK (0.66) | MERTKBTKJAK3 | |
| SCHEMBL13048667 | 0.83 | SYK (0.57) | HTR2AHTR2CBTKSYKJAK3 | |
| SCHEMBL13048682 | 0.82 | HTR2A (0.57) | MERTKHTR2AHTR2CBTKSYK | |
| SCHEMBL13048674 | 0.82 | CDK2 (0.60) | MERTKHTR2AHTR2CBTKSYK | |
| SCHEMBL13048670 | 0.81 | HTR2A (0.59) | HTR2AHTR2CBTKSYKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298557-A1 | PYRAZOLOPYRIMIDINE COMPOUND | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298557-A1 | PYRAZOLOPYRIMIDINE COMPOUND | SYK, LCK, FYN | MERTK 35/4885HTR2A 4430/4885HTR2C 4181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.