Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | ALPL | P05186 | 2/20 | 0.41 |
| ▸ | ALPI | P09923 | 2/20 | 0.41 |
| ▸ | ALPG | P10696 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14467034 | 0.87 | ERBB2 (0.41) | ERBB2MAP4K4HSP90AB1HSP90AA1 | |
| SCHEMBL1966212 | 0.87 | ERBB2 (0.53) | ERBB2MAP4K4HSP90AB1HSP90AA1 | |
| SCHEMBL3126758 | 0.86 | HSP90AB1 (0.51) | TSHRERBB2MAP4K4HSP90AB1HSP90AA1 | |
| SCHEMBL4339904 | 0.86 | ERBB2 (0.52) | ERBB2MAP4K4HSP90AB1HSP90AA1 | |
| SCHEMBL3111577 | 0.85 | HSP90B1 (0.50) | ERBB2MAP4K4HSP90AB1HSP90AA1 | |
| SCHEMBL3744472 | 0.83 | HSP90AA1 (0.47) | KDM4EMAPTERBB2MAP4K4HSP90AB1 | |
| SCHEMBL3740870 | 0.81 | ERBB2 (0.43) | ERBB2MAP4K4HSP90AB1HSP90AA1 | |
| SCHEMBL3114495 | 0.81 | HSP90AA1 (0.39) | TSHRERBB2MAP4K4HSP90AB1HSP90AA1 | |
| SCHEMBL4342949 | 0.80 | HSP90AA1 (0.53) | MAP4K4HSP90AB1HSP90AA1 | |
| SCHEMBL5038927 | 0.79 | HSP90AB1 (0.38) | ERBB2MAP4K4HSP90AB1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100292255-A1 | Therapeutic Compounds and Their Use in Treating Diseases and Disorders | MYRIAD PHARMACEUTICALS, INC. (US) | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292255-A1 | Therapeutic Compounds and Their Use in Treating Diseases and Disorders | VHL, CLN6, CFTR | GAA 16/4885ALPL 3088/4885ALPI 681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.