Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CASP7 | P55210 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1622579 | 0.89 | MEN1 (0.45) | MEN1KMT2ASMAD3CHEK2TSHR | |
| SCHEMBL6109608 | 0.89 | MEN1 (0.45) | MEN1KMT2ASMAD3CHEK2TSHR | |
| SCHEMBL1624224 | 0.89 | MEN1 (0.45) | MEN1KMT2ASMAD3CHEK2TSHR | |
| SCHEMBL12721005 | 0.87 | MEN1 (0.51) | MEN1KMT2ASMAD3CHEK2TSHR | |
| SCHEMBL1623468 | 0.87 | MEN1 (0.51) | MEN1KMT2ASMAD3CHEK2TSHR | |
| SCHEMBL1623464 | 0.87 | MEN1 (0.51) | MEN1KMT2ASMAD3CHEK2TSHR | |
| SCHEMBL1084462 | 0.87 | TSHR (0.58) | MEN1KMT2ASMAD3CHEK2TSHR | |
| Hydrochloric Acid SCHEMBL1623838 | 0.86 | MEN1 (0.50) | MEN1KMT2ASMAD3CHEK2TSHR | |
| Hydrochloric Acid SCHEMBL1623836 | 0.86 | MEN1 (0.50) | MEN1KMT2ASMAD3CHEK2TSHR | |
| SCHEMBL1084876 | 0.86 | CHEK2 (0.49) | MEN1KMT2ASMAD3CHEK2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8283354-B2 | Voltage gated sodium and calcium channel inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-10-09 | — | — | US | disclosed |
| US-8283354-B2 | Voltage gated sodium and calcium channel inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-10-09 | — | — | US | disclosed |