Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ACP1 | P24666 | 2/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | GBA1 | P04062 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13080750 | 0.94 | TSHR (0.54) | TSHRTP53MAPTKDM4ELMNA | |
| SCHEMBL13080748 | 0.92 | TSHR (0.58) | TSHRTP53MAPTKDM4ELMNA | |
| SCHEMBL13080768 | 0.91 | TSHR (0.46) | TSHRTP53MAPTKDM4ELMNA | |
| SCHEMBL1624084 | 0.89 | CHEK2 (0.55) | TSHRTP53MAPTKDM4ELMNA | |
| SCHEMBL13080763 | 0.86 | TSHR (0.45) | TSHRTP53MAPTKDM4ELMNA | |
| SCHEMBL1623413 | 0.84 | CHEK2 (0.54) | TSHRTP53MAPTKDM4ELMNA | |
| SCHEMBL13769804 | 0.84 | CHEK2 (0.45) | TSHRTP53MAPTKDM4ELMNA | |
| SCHEMBL13080757 | 0.83 | TSHR (0.48) | TSHRTP53MAPTKDM4ELMNA | |
| SCHEMBL1622250 | 0.81 | SMAD3 (0.56) | TSHRTP53MAPTKDM4ELMNA | |
| SCHEMBL1623757 | 0.81 | SMAD3 (0.56) | TSHRTP53MAPTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8283354-B2 | Voltage gated sodium and calcium channel inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-10-09 | — | — | US | disclosed |