Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 4/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13036285 | 1.00 | TACR1 (0.41) | TACR1FFAR1MAPTKDM4EMEN1 | |
| SCHEMBL13036282 | 1.00 | TACR1 (0.41) | TACR1FFAR1MAPTKDM4EMEN1 | |
| SCHEMBL13036401 | 0.93 | TACR1 (0.44) | TACR1FFAR1MAPTKDM4EMEN1 | |
| SCHEMBL13036402 | 0.93 | TACR1 (0.44) | TACR1FFAR1MAPTKDM4EMEN1 | |
| SCHEMBL13036404 | 0.89 | FFAR1 (0.41) | TACR1FFAR1MAPTMEN1CYP1A2 | |
| SCHEMBL13036403 | 0.89 | FFAR1 (0.41) | TACR1FFAR1MAPTMEN1CYP1A2 | |
| SCHEMBL13084688 | 0.89 | NPSR1 (0.35) | MAPTTHRBBLM | |
| SCHEMBL13036417 | 0.89 | NPSR1 (0.35) | MAPTTHRBBLM | |
| SCHEMBL13036416 | 0.89 | NPSR1 (0.35) | MAPTTHRBBLM | |
| SCHEMBL13036366 | 0.87 | IDO1 (0.38) | MAPTKDM4ETHRBRECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899320-B1 | SUBSTITUTED PYRR0LIDIN-2-0NES , PIPERIDIN-2-0NES AND ISOTHIAZOLIDINE-1, 1-DIOXIDES, THEIR USE AS KV1 .5 POTASSIUM CHANNEL BLOCKERS AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM | SANOFI AVENTIS (FR) | 2010-10-20 | — | — | EP | disclosed |