Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | TOP1 | P11387 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL537612 | 0.93 | KCNH2 (0.51) | KCNH2TOP1POLBKDM4EPRKD3 | |
| SCHEMBL2675223 | 0.88 | KCNH2 (0.56) | KCNH2TOP1 | |
| SCHEMBL537083 | 0.87 | KCNH2 (0.54) | KCNH2TOP1POLBKDM4EPRKD3 | |
| SCHEMBL537074 | 0.87 | KCNH2 (0.54) | KCNH2TOP1POLBKDM4EPRKD3 | |
| SCHEMBL13093315 | 0.84 | KCNH2 (0.59) | KCNH2TOP1 | |
| SCHEMBL537000 | 0.82 | KCNH2 (0.41) | KCNH2TOP1POLBKDM4EPRKD3 | |
| SCHEMBL537045 | 0.82 | KCNH2 (0.59) | KCNH2TOP1 | |
| SCHEMBL15052748 | 0.82 | KCNH2 (0.59) | KCNH2TOP1 | |
| SCHEMBL15052745 | 0.82 | KCNH2 (0.59) | KCNH2TOP1 | |
| SCHEMBL2675006 | 0.82 | KCNH2 (0.59) | KCNH2TOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010115184-A2 | HYDROXYTHIENOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS | ACHILLION PHARMACEUTICALS, INC. (US) | 2010-10-07 | — | — | WO | disclosed |