Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 5/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PI4KA | P42356 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8617736 | 0.83 | CYP2D6 (0.43) | CYP2A6CYP2D6CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL10964154 | 0.80 | CYP2D6 (0.46) | CYP2A6CYP2D6CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL19569868 | 0.78 | CYP2A6 (0.66) | CYP2A6CYP11B2CYP11B1PIM1PIM2 | |
| SCHEMBL26415549 | 0.78 | CYP2A6 (0.40) | CYP2A6CYP2D6CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL30261430 | 0.77 | CYP2A6 (0.56) | CYP2A6CYP11B2CYP11B1CYP1A2HCRTR1 | |
| SCHEMBL4582651 | 0.77 | CYP2A6 (0.54) | CYP2A6CYP3A4PIM2 | |
| SCHEMBL5144659 | 0.77 | CYP2A6 (0.56) | CYP2A6CYP11B2CYP11B1CYP1A2HCRTR1 | |
| SCHEMBL469126 | 0.77 | HCRTR1 (0.36) | CYP2A6CYP11B2CYP11B1HCRTR1HCRTR2 | |
| SCHEMBL30338515 | 0.76 | PIM1 (0.43) | CYP2D6CYP19A1CYP2C9CYP2C19CYP11B2 | |
| SCHEMBL7880401 | 0.76 | HCRTR1 (0.42) | CYP2A6HCRTR1HCRTR2PIM1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293769-B2 | CSF-1R inhibitors, compositions, and methods of use | NOVARTIS AG (CH) | 2012-10-23 | — | — | US | disclosed |
| US-20100261679-A1 | CSF-1R, Inhibitors, Compositions, and Methods of Use | NOVARTIS AG (CH) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261679-A1 | CSF-1R, Inhibitors, Compositions, and Methods of Use | CSF1R, CSF3R, MSR1 | CYP2A6 3442/4885CYP2D6 3619/4885CYP19A1 1639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.