Known targets — ChEMBL curated mechanism
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The experimentally established mechanism targets of Erythromycin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 8/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 5/20 | 1.00 |
| ▸ | MLNR | O43193 | 3/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | ALB | P02768 | 1/20 | 1.00 |
| ▸ | CNR1 | P21554 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | AOX1 | Q06278 | 1/20 | 1.00 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 1.00 |
| ▸ | SLCO1B3 | Q9NPD5 | 2/20 | 0.92 |
| ▸ | SLCO1B1 | Q9Y6L6 | 2/20 | 0.92 |
| ▸ | AR | P10275 | 1/20 | 0.92 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.92 |
| ▸ | PGR | P06401 | 1/20 | 0.83 |
| ▸ | HTR1A | P08908 | 1/20 | 0.83 |
| ▸ | DRD1 | P21728 | 1/20 | 0.83 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Erythromycin SCHEMBL13697563 | 1.00 | CYP3A4 (1.00) | CYP3A4KCNH2MLNRABCB1TSHR | |
| Erythromycin SCHEMBL15472911 | 1.00 | CYP3A4 (1.00) | CYP3A4KCNH2MLNRABCB1TSHR | |
| Erythromycin SCHEMBL17119502 | 1.00 | CYP3A4 (1.00) | CYP3A4KCNH2MLNRABCB1TSHR | |
| Erythromycin SCHEMBL2328474 | 1.00 | CYP3A4 (1.00) | CYP3A4KCNH2MLNRABCB1TSHR | |
| Erythromycin SCHEMBL13900514 | 1.00 | CYP3A4 (1.00) | CYP3A4KCNH2MLNRABCB1TSHR | |
| Erythromycin SCHEMBL24415240 | 1.00 | CYP3A4 (1.00) | CYP3A4KCNH2MLNRABCB1TSHR | |
| Erythromycin SCHEMBL14342511 | 1.00 | CYP3A4 (1.00) | CYP3A4KCNH2MLNRABCB1TSHR | |
| Erythromycin SCHEMBL13930075 | 1.00 | CYP3A4 (1.00) | CYP3A4KCNH2MLNRABCB1TSHR | |
| Erythromycin SCHEMBL20833993 | 1.00 | CYP3A4 (1.00) | CYP3A4KCNH2MLNRABCB1TSHR | |
| Erythromycin SCHEMBL18211506 | 1.00 | CYP3A4 (1.00) | CYP3A4KCNH2MLNRABCB1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7807418-B2 | Method for producing hybrid polyketide synthases | BIOTICA TECHNOLOGY LIMITED (GB) | 2010-10-05 | — | — | US | disclosed |