SCHEMBL13110490

SCHEMBL13110490

COC(=O)CC1COc2cc(OCc3cccc(-c4c(C)cc(OCc5ccccc5)cc4C)c3)ccc21

nearest known ligand 0.85

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 20/20 0.85
GNA15 P30679 1/20 0.69
SLC10A1 Q14973 1/20 0.69
ABCC2 Q92887 1/20 0.69
SLCO1B3 Q9NPD5 1/20 0.69
SLCO1B1 Q9Y6L6 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16123744 0.93 FFAR1 (0.74) FFAR1GNA15SLC10A1ABCC2SLCO1B3
SCHEMBL13110447 0.93 FFAR1 (0.83) FFAR1GNA15SLC10A1ABCC2SLCO1B3
SCHEMBL15125747 0.93 FFAR1 (0.74) FFAR1GNA15SLC10A1ABCC2SLCO1B3
SCHEMBL13110442 0.93 FFAR1 (0.82) FFAR1GNA15SLC10A1ABCC2SLCO1B3
SCHEMBL16123789 0.92 FFAR1 (0.73) FFAR1GNA15SLC10A1ABCC2SLCO1B3
SCHEMBL1633142 0.92 FFAR1 (1.00) FFAR1GNA15SLC10A1ABCC2SLCO1B3
SCHEMBL16123734 0.92 FFAR1 (0.72) FFAR1GNA15SLC10A1ABCC2SLCO1B3
SCHEMBL16684804 0.91 FFAR1 (0.72) FFAR1GNA15SLC10A1ABCC2SLCO1B3
SCHEMBL16123792 0.91 FFAR1 (0.71) FFAR1GNA15SLC10A1ABCC2SLCO1B3
SCHEMBL16123739 0.91 FFAR1 (0.71) FFAR1GNA15SLC10A1ABCC2SLCO1B3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7820837-B2 ethyl {6-[(3-phenoxybenzyl)oxy]-3,4-dihydronaphthalen-1-yl}acetate; having a GPR40 receptor function modulating action and being useful as an insulin secretagogue or a pharmaceutical agent for the prophylaxis or treatment of diabetes TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-10-26 US disclosed
US-7820837-B2 ethyl {6-[(3-phenoxybenzyl)oxy]-3,4-dihydronaphthalen-1-yl}acetate; having a GPR40 receptor function modulating action and being useful as an insulin secretagogue or a pharmaceutical agent for the prophylaxis or treatment of diabetes TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-10-26 US disclosed