Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 12/20 | 0.64 |
| ▸ | GSK3B | P49841 | 7/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14598761 | 1.00 | CDK2 (0.64) | CDK2GSK3BALDH1A1CCNA2CCNA1 | |
| SCHEMBL13119345 | 0.96 | CDK2 (0.61) | CDK2GSK3BCCNA2CCNA1CCNE1 | |
| SCHEMBL15576816 | 0.96 | CDK2 (0.61) | CDK2GSK3BCCNA2CCNA1CCNE1 | |
| SCHEMBL13119558 | 0.93 | CDK2 (0.61) | CDK2GSK3BALDH1A1CCNA2CCNA1 | |
| SCHEMBL15381299 | 0.93 | CDK2 (0.61) | CDK2GSK3BALDH1A1CCNA2CCNA1 | |
| SCHEMBL13120252 | 0.90 | CDK2 (0.55) | CDK2GSK3B | |
| SCHEMBL13119651 | 0.89 | CDK2 (0.57) | CDK2GSK3BCCNA2CCNA1CCNE1 | |
| SCHEMBL13120122 | 0.88 | CDK2 (0.54) | CDK2GSK3B | |
| SCHEMBL13120041 | 0.88 | CDK2 (0.54) | CDK2GSK3B | |
| SCHEMBL13119420 | 0.88 | CDK2 (0.72) | CDK2GSK3BCCNA2CCNA1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8586576-B2 | Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2013-11-19 | — | — | US | disclosed |
| US-8580782-B2 | Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2013-11-12 | — | — | US | disclosed |
| US-8580782-B2 | Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2013-11-12 | — | — | US | disclosed |
| US-7807683-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2010-10-05 | — | — | US | disclosed |
| US-7807683-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2010-10-05 | — | — | US | disclosed |