Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 13/20 | 0.57 |
| ▸ | GSK3B | P49841 | 8/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13120284 | 0.90 | CDK2 (0.60) | CDK2GSK3BCCNE1CCNA2CCNA1 | |
| SCHEMBL14561755 | 0.88 | GSK3B (0.56) | CDK2GSK3BCCNE1CCNA2CCNA1 | |
| SCHEMBL13120304 | 0.88 | CDK2 (0.58) | CDK2GSK3BCCNE1 | |
| SCHEMBL13120278 | 0.87 | GSK3B (0.57) | CDK2GSK3BCCNE1CCNA2CCNA1 | |
| SCHEMBL13120285 | 0.87 | GSK3B (0.57) | CDK2GSK3BCCNE1CCNA2CCNA1 | |
| SCHEMBL13120297 | 0.86 | CDK2 (0.58) | CDK2GSK3BCCNE1CCNA2CCNA1 | |
| SCHEMBL13120264 | 0.86 | CDK2 (0.60) | CDK2GSK3BCCNE1CCNA2CCNA1 | |
| SCHEMBL13120303 | 0.86 | GSK3B (0.58) | CDK2GSK3BCCNE1CCNA2CCNA1 | |
| SCHEMBL13120277 | 0.86 | CDK2 (0.56) | CDK2GSK3BCCNE1CCNA2CCNA1 | |
| SCHEMBL13120150 | 0.84 | CDK2 (0.58) | CDK2GSK3BCCNE1CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7807683-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2010-10-05 | — | — | US | disclosed |
| US-7807683-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2010-10-05 | — | — | US | disclosed |