Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARK3 | P27448 | 14/20 | 0.92 |
| ▸ | SGK1 | O00141 | 2/20 | 0.77 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.77 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.77 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.77 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.77 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.77 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.77 |
| ▸ | JAK2 | O60674 | 2/20 | 0.77 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.77 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.77 |
| ▸ | EGFR | P00533 | 2/20 | 0.77 |
| ▸ | RAF1 | P04049 | 2/20 | 0.77 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.77 |
| ▸ | LCK | P06239 | 2/20 | 0.77 |
| ▸ | CSF1R | P07333 | 2/20 | 0.77 |
| ▸ | MET | P08581 | 2/20 | 0.77 |
| ▸ | HCK | P08631 | 2/20 | 0.77 |
| ▸ | KIT | P10721 | 2/20 | 0.77 |
| ▸ | PIM1 | P11309 | 2/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13126184 | 0.96 | MARK3 (1.00) | MARK3SGK1PIK3CDCHEK1MAPK13 | |
| SCHEMBL2813260 | 0.91 | MARK3 (0.84) | MARK3SGK1PIK3CDCHEK1MAPK13 | |
| SCHEMBL13126141 | 0.88 | MARK3 (0.88) | MARK3SGK1PIK3CDCHEK1MAPK13 | |
| SCHEMBL2805197 | 0.87 | MARK3 (1.00) | MARK3SGK1PIK3CDCHEK1MAPK13 | |
| SCHEMBL3767696 | 0.87 | MARK3 (0.78) | MARK3SGK1PIK3CDCHEK1MAPK13 | |
| SCHEMBL13126138 | 0.86 | MARK3 (0.86) | MARK3SGK1PIK3CDCHEK1MAPK13 | |
| SCHEMBL13126175 | 0.85 | MARK3 (0.85) | MARK3SGK1PIK3CDCHEK1MAPK13 | |
| SCHEMBL13126162 | 0.84 | MARK3 (0.82) | MARK3SGK1PIK3CDCHEK1MAPK13 | |
| SCHEMBL13126161 | 0.84 | MARK3 (0.82) | MARK3SGK1PIK3CDCHEK1MAPK13 | |
| SCHEMBL13126170 | 0.84 | MARK3 (0.81) | MARK3SGK1PIK3CDCHEK1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100240647-A1 | Treatment of Alzheimer's Disease and Related Conditions | MERCK & CO., INC. | 2010-09-23 | — | — | US | disclosed |
| WO-2007085873-A1 | TREATMENT OF ALZHEIMER'S DISEASE AND RELATED CONDITIONS | MERCK SHARP & DOHME LIMITED (GB) | 2007-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240647-A1 | Treatment of Alzheimer's Disease and Related Conditions | MAPT, MAP2, TTBK1 | MARK3 12/4885SGK1 242/4885PIK3CD 1282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.