Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 15/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 13/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.40 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.40 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.40 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.40 |
| ▸ | RPS27 | P42677 | 4/20 | 0.39 |
| ▸ | CSF1R | P07333 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13126796 | 0.93 | MAPK8 (0.38) | MAPK8MAPK9MAPK10PRKD2PRKD3 | |
| SCHEMBL3459965 | 0.89 | MAPK8 (0.39) | MAPK8MAPK9MAPK10PRKD2PRKD3 | |
| SCHEMBL12946927 | 0.89 | MAPK8 (0.42) | MAPK8MAPK9MAPK10PRKD2PRKD3 | |
| SCHEMBL12947166 | 0.89 | MAPK8 (0.41) | MAPK8MAPK9MAPK10PRKD2PRKD3 | |
| SCHEMBL12947069 | 0.89 | MAPK8 (0.41) | MAPK8MAPK9MAPK10PRKD2PRKD3 | |
| SCHEMBL12946905 | 0.88 | MAPK8 (0.43) | MAPK8MAPK9MAPK10PRKD2PRKD3 | |
| SCHEMBL12946555 | 0.88 | MAPK8 (0.42) | MAPK8MAPK9MAPK10PRKD2PRKD3 | |
| SCHEMBL12947099 | 0.87 | MAPK8 (0.41) | MAPK8MAPK9MAPK10PRKD2PRKD3 | |
| SCHEMBL13125823 | 0.86 | MEN1 (0.46) | PIK3CDPIK3R2PIK3CGKISS1R | |
| SCHEMBL12947098 | 0.85 | MAPK8 (0.41) | MAPK8MAPK9MAPK10PRKD3RPS27 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816353-B2 | P70S6 kinase modulators and method of use | EXELIXIS, INC. (US) | 2010-10-19 | — | — | US | disclosed |