Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 6/20 | 0.62 |
| ▸ | PPARA | Q07869 | 1/20 | 0.58 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.56 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.56 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.56 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.56 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.54 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1314770 | 0.99 | SPHK1 (0.64) | SPHK1PPARAS1PR1S1PR2S1PR3 | |
| SCHEMBL1312757 | 0.99 | SPHK1 (0.64) | SPHK1PPARAS1PR1S1PR2S1PR3 | |
| SCHEMBL1312134 | 0.99 | SPHK1 (0.64) | SPHK1PPARAS1PR1S1PR2S1PR3 | |
| SCHEMBL3266257 | 0.89 | SPHK1 (0.66) | SPHK1PPARAS1PR1S1PR2S1PR3 | |
| SCHEMBL26887336 | 0.88 | SPHK1 (0.68) | SPHK1PPARAS1PR1S1PR2S1PR3 | |
| SCHEMBL15176192 | 0.87 | SPHK1 (0.71) | SPHK1S1PR1SPHK2NPC1RAB9A | |
| SCHEMBL26887338 | 0.87 | SPHK1 (0.71) | SPHK1S1PR1SPHK2NPC1RAB9A | |
| SCHEMBL1312625 | 0.87 | SPHK1 (0.71) | SPHK1S1PR1SPHK2NPC1RAB9A | |
| SCHEMBL3264894 | 0.87 | SPHK1 (0.67) | SPHK1PPARAS1PR1S1PR2S1PR3 | |
| SCHEMBL26887329 | 0.86 | SPHK1 (0.70) | SPHK1PPARAS1PR1S1PR2S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110275673-A1 | INHIBITORS OF SPHINGOSINE KINASE 1 | GENZYME CORPORATION | 2011-11-10 | — | — | US | disclosed |
| WO-2010033701-A2 | INHIBITORS OF SPHINGOSINE KINASE 1 | GENZYME CORPORATION (US) | 2010-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275673-A1 | INHIBITORS OF SPHINGOSINE KINASE 1 | SPHK1, SPHK2, S1PR1 | SPHK1 1/4885PPARA 2761/4885S1PR1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.