Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19470007 | 0.85 | TOP2A (0.34) | TOP2A | |
| SCHEMBL335601 | 0.85 | TOP2A (0.34) | TOP2A | |
| SCHEMBL335751 | 0.81 | TOP2A (0.46) | TOP2A | |
| SCHEMBL335130 | 0.80 | TOP2A (0.49) | TOP2A | |
| Hydrochloric Acid SCHEMBL1312760 | 0.79 | TOP2A (0.35) | TOP2A | |
| SCHEMBL12113978 | 0.79 | KCNA3 (0.42) | TOP2A | |
| SCHEMBL909909 | 0.78 | — | — | |
| SCHEMBL910258 | 0.74 | TOP2A (0.39) | TOP2A | |
| SCHEMBL910118 | 0.74 | TOP2A (0.39) | TOP2A | |
| SCHEMBL1312096 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110275661-A1 | TRICYCLIC NITROGEN COMPOUNDS USED AS ANTIBACTERIALS | GLAXO GROUP LIMITED | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275661-A1 | TRICYCLIC NITROGEN COMPOUNDS USED AS ANTIBACTERIALS | NRDC, NGLY1, NISCH | TOP2A 525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.