Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 2/20 | 0.68 |
| ▸ | BCHE | P06276 | 1/20 | 0.52 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.49 |
| ▸ | CA12 | O43570 | 3/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.48 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | CA9 | Q16790 | 3/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | DDX3X | O00571 | 3/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13527252 | 0.89 | MIF (0.60) | MIFBCHESPHK1CA12CA1 | |
| SCHEMBL15060892 | 0.87 | MIF (0.62) | MIFBCHESPHK1CA12CA1 | |
| SCHEMBL15923943 | 0.85 | MIF (0.71) | MIFBCHESPHK1CYP19A1CA12 | |
| SCHEMBL13527245 | 0.84 | MIF (0.69) | MIFBCHESPHK1CYP19A1CA12 | |
| SCHEMBL18031111 | 0.83 | MIF (0.97) | MIFBCHESPHK1CYP19A1DDX3X | |
| SCHEMBL15923549 | 0.83 | MIF (0.97) | MIFBCHESPHK1CYP19A1DDX3X | |
| SCHEMBL16271203 | 0.82 | MIF (0.71) | MIFCYP19A1MAOANOTUMDDX3X | |
| SCHEMBL15060974 | 0.82 | MIF (0.71) | MIFBCHESPHK1CA12CA1 | |
| SCHEMBL13527214 | 0.82 | MIF (0.67) | MIFBCHESPHK1CYP19A1CA12 | |
| SCHEMBL13527045 | 0.82 | MIF (0.62) | MIFBCHESPHK1CYP19A1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110275673-A1 | INHIBITORS OF SPHINGOSINE KINASE 1 | GENZYME CORPORATION | 2011-11-10 | — | — | US | disclosed |
| WO-2010033701-A2 | INHIBITORS OF SPHINGOSINE KINASE 1 | GENZYME CORPORATION (US) | 2010-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275673-A1 | INHIBITORS OF SPHINGOSINE KINASE 1 | SPHK1, SPHK2, S1PR1 | MIF 978/4885BCHE 3532/4885SPHK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.