Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 14/20 | 0.41 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2869006 | 0.88 | KDR (0.43) | SYKKARS1KDR | |
| SCHEMBL2869013 | 0.88 | KDR (0.43) | SYKKARS1KDR | |
| SCHEMBL2862665 | 0.87 | SYK (0.39) | SYKKARS1KDR | |
| SCHEMBL2862657 | 0.87 | SYK (0.39) | SYKKARS1KDR | |
| SCHEMBL2862460 | 0.84 | SYK (0.51) | SYKKARS1KDR | |
| SCHEMBL2871174 | 0.84 | SYK (0.50) | SYKKARS1CDK1CDK4CCNE1 | |
| SCHEMBL2862469 | 0.84 | SYK (0.51) | SYKKARS1KDR | |
| SCHEMBL2871166 | 0.84 | SYK (0.50) | SYKKARS1CDK1CDK4CCNE1 | |
| SCHEMBL13136329 | 0.83 | SYK (0.47) | SYKKDR | |
| SCHEMBL13136330 | 0.81 | SYK (0.40) | SYKKARS1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-7803801-B2 | Aminopyridine compounds having Syk inhibitory activity | JAPAN TOBACCO, INC. (JP) | 2010-09-28 | — | — | US | disclosed |