SCHEMBL13136393

SCHEMBL13136393

Cc1ccnc(Nc2cccc(-c3cnc([C@@H]4COC(=O)N4CC(=O)O)s3)n2)c1

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SYK P43405 14/20 0.51
KARS1 Q15046 6/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13136388 0.92 SYK (0.47) SYKKARS1
SCHEMBL13136394 0.91 SYK (0.46) SYKKARS1
SCHEMBL13136390 0.89 SYK (0.46) SYKKARS1
SCHEMBL2862972 0.87 SYK (0.47) SYKKARS1
SCHEMBL2862970 0.87 SYK (0.47) SYKKARS1
SCHEMBL13136219 0.81 SYK (0.53) SYKKARS1
SCHEMBL2863562 0.77 SYK (0.55) SYKKARS1
SCHEMBL2864036 0.77 SYK (0.48) SYKKARS1
SCHEMBL2864041 0.77 SYK (0.48) SYKKARS1
SCHEMBL13136358 0.77 SYK (0.50) SYKKARS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7803801-B2 Aminopyridine compounds having Syk inhibitory activity JAPAN TOBACCO, INC. (JP) 2010-09-28 US disclosed
US-7803801-B2 Aminopyridine compounds having Syk inhibitory activity JAPAN TOBACCO, INC. (JP) 2010-09-28 US disclosed