Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12166529 | 0.82 | KMT2A (0.50) | NPC1KMT2AMEN1CYP1A2SMN1; SMN2 | |
| SCHEMBL2919829 | 0.81 | NPC1 (0.49) | NPC1KMT2AMEN1CYP1A2SMN1; SMN2 | |
| SCHEMBL8099701 | 0.79 | KMT2A (0.47) | NPC1KMT2AMEN1CYP1A2SMN1; SMN2 | |
| SCHEMBL12713415 | 0.79 | NPC1 (0.47) | NPC1KMT2AMEN1CYP1A2SMN1; SMN2 | |
| Water SCHEMBL27477225 | 0.78 | KMT2A (0.46) | NPC1KMT2AMEN1CYP1A2SMN1; SMN2 | |
| SCHEMBL1847138 | 0.78 | KMT2A (0.48) | NPC1KMT2AMEN1CYP1A2SMN1; SMN2 | |
| SCHEMBL1847139 | 0.78 | KMT2A (0.48) | NPC1KMT2AMEN1CYP1A2SMN1; SMN2 | |
| SCHEMBL26981928 | 0.78 | KMT2A (0.46) | NPC1KMT2AMEN1CYP1A2SMN1; SMN2 | |
| SCHEMBL1939079 | 0.77 | NPC1 (0.48) | NPC1KMT2AMEN1CYP1A2SMN1; SMN2 | |
| SCHEMBL1939080 | 0.77 | NPC1 (0.48) | NPC1KMT2AMEN1CYP1A2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9657031-B2 | Ant-ligands molecules and biological applications | UNIVERSITE DE VERSAILLES-SAINT-QUENTIN-EN-YVELINES (FR) | 2017-05-23 | — | — | US | disclosed |
| US-8288395-B2 | Pyrimido-benzimidzole derivatives and the use thereof in the form of agonists or antagonists of melanocortin receptors | IPSEN PHARMA S.A.S. (FR) | 2012-10-16 | — | — | US | disclosed |
| US-20100256135-A1 | PYRIMIDO-BENZIMIDZOLE DERIVATIVES AND THE USE THEREOF IN THE FORM OF AGONISTS OR ANTAGONISTS OF MELANOCORTIN RECEPTORS | IPSEN PHARMA S.A.S. (FR) | 2010-10-07 | — | — | US | disclosed |
| US-7763725-B2 | used for treating metabolic, nervous sytsem and skin disorders,inflammatory diseases, obesity, cachexia, erectile dysfunction, neuropathic pain, or as antidepressants, anxiolytic and anticarcinogenic agents | IPSEN PHARMA S.A.S. (FR) | 2010-07-27 | — | — | US | disclosed |
| US-20090209531-A1 | Pyrimido-Benzimidazole Derivatives and the Use Thereof in the Form of Agonists and Antagonists of Melanocortin Receptors | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES, S.A.S. (FR) | 2009-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256135-A1 | PYRIMIDO-BENZIMIDZOLE DERIVATIVES AND THE USE THEREOF IN THE FORM OF AGONISTS OR ANTAGONISTS OF MELANOCORTIN RECEPTORS | MC4R, MC5R, MC1R | NPC1 3136/4885KMT2A 2410/4885MEN1 1090/4885 |
| US-20090209531-A1 | Pyrimido-Benzimidazole Derivatives and the Use Thereof in the Form of Agonists and Antagonists of Melanocortin Receptors | MC4R, MC5R, MC1R | NPC1 3084/4885KMT2A 2207/4885MEN1 856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.