Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL537356 | 0.91 | CYP2C9 (0.47) | CYP2C9CYP2D6KMT2AMEN1HPGD | |
| SCHEMBL536729 | 0.82 | KMT2A (0.47) | CYP2C9CYP2D6KMT2AMEN1HPGD | |
| SCHEMBL537416 | 0.82 | CYP2D6 (0.52) | CYP2C9CYP2D6KMT2AMEN1HPGD | |
| SCHEMBL537286 | 0.76 | CYP2C9 (0.54) | CYP2C9CYP2D6KMT2AMEN1HPGD | |
| SCHEMBL12833903 | 0.70 | CDK4 (0.47) | CYP2C9CYP2D6KMT2AMEN1HPGD | |
| SCHEMBL26307601 | 0.69 | CYP2C9 (1.00) | CYP2C9CYP2D6KMT2AMEN1HPGD | |
| SCHEMBL12833435 | 0.68 | CDK4 (0.47) | CYP2C9CYP2D6KMT2AMEN1HPGD | |
| SCHEMBL5653271 | 0.68 | CYP2D6 (0.61) | CYP2C9CYP2D6KMT2AMEN1HPGD | |
| SCHEMBL10379079 | 0.68 | CYP2C9 (0.73) | CYP2C9CYP2D6TSHRSMN1; SMN2KDM4E | |
| SCHEMBL29818241 | 0.67 | TSHR (0.73) | CYP2C9CYP2D6KMT2AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010114896-A1 | SUBSTITUTED INDOLO-PYRIDINONE COMPOUNDS | ARQULE, INC. (US) | 2010-10-07 | — | — | WO | disclosed |