Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 12/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 0.75 |
| ▸ | MITF | O75030 | 3/20 | 0.72 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.72 |
| ▸ | NPC1 | O15118 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13148014 | 0.92 | CSF1R (1.00) | CSF1RPOLBMITFHSP90AA1NPC1 | |
| SCHEMBL13148031 | 0.89 | CSF1R (1.00) | CSF1RPOLBMITFHSP90AA1NPC1 | |
| SCHEMBL13180531 | 0.88 | CSF1R (1.00) | CSF1RPOLBMITFHSP90AA1NPC1 | |
| SCHEMBL5093277 | 0.85 | CSF1R (1.00) | CSF1RPOLBMITFHSP90AA1NPC1 | |
| SCHEMBL13148038 | 0.85 | CSF1R (1.00) | CSF1RPOLBMITFHSP90AA1NPC1 | |
| SCHEMBL13148062 | 0.84 | CSF1R (1.00) | CSF1RPOLBMITFHSP90AA1NPC1 | |
| SCHEMBL13148057 | 0.83 | CSF1R (1.00) | CSF1RPOLBMITFHSP90AA1NPC1 | |
| SCHEMBL13148136 | 0.81 | CSF1R (0.72) | CSF1RPOLB | |
| SCHEMBL13148049 | 0.80 | CSF1R (1.00) | CSF1RPOLBMITFHSP90AA1NPC1 | |
| SCHEMBL13148075 | 0.79 | CSF1R (0.81) | CSF1RPOLBMITFHSP90AA1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790724-B2 | c-fms kinase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-09-07 | — | — | US | disclosed |
| US-7790724-B2 | c-fms kinase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-09-07 | — | — | US | disclosed |
| US-7429603-B2 | Such as 5-nitro-furan-2-carboxylic acid (2-piperidin-1-yl-phenyl)-amide; diabetes, angiogenesis, psoriasis, restenosis, schizophrenia, rheumatoid arthritis, cardiovascular disease, cancer | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2008-09-30 | — | — | US | disclosed |