Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL713 | 0.78 | KDM4E (0.46) | KDM4EGAATSHRSMN1; SMN2 | |
| SCHEMBL993 | 0.78 | KDM4E (0.46) | KDM4EGAATSHRSMN1; SMN2 | |
| SCHEMBL22075818 | 0.72 | KDM4E (0.53) | KDM4EGAATSHRSMN1; SMN2 | |
| SCHEMBL7267947 | 0.67 | KDM4E (0.47) | KDM4EGAATSHRSMN1; SMN2 | |
| SCHEMBL9876336 | 0.64 | TSHR (0.42) | KDM4EGAATSHRSMN1; SMN2 | |
| SCHEMBL1056 | 0.62 | KDM4E (0.39) | KDM4EGAATSHR | |
| SCHEMBL941 | 0.62 | TSHR (0.40) | KDM4EGAATSHRSMN1; SMN2 | |
| SCHEMBL14334526 | 0.59 | FGFR1 (0.40) | KDM4EGAATSHRSMN1; SMN2 | |
| SCHEMBL31460301 | 0.59 | GAA (1.00) | KDM4EGAATSHRSMN1; SMN2 | |
| SCHEMBL16125139 | 0.59 | KDM4E (0.31) | KDM4EGAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5360800-A | Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives | GLAXO GROUP LIMITED (GB) | 1994-11-01 | — | — | US | disclosed |
| EP-0306323-A2 | Lactam derivatives | GLAXO GROUP LIMITED (GB) | 1989-03-08 | — | — | EP | disclosed |