Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK2 | Q13002 | 3/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.38 |
| ▸ | RAD51 | Q06609 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | TERT | O14746 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13151837 | 0.88 | GRIK2 (0.41) | GRIK2GRIK1RAD51KDM4EALDH1A1 | |
| SCHEMBL13152603 | 0.88 | MAPT (0.44) | GRIK2GRIK1RAD51KDM4EALDH1A1 | |
| SCHEMBL2878944 | 0.85 | ESR1 (0.38) | GRIK2GRIK1RAD51KDM4EALDH1A1 | |
| SCHEMBL10249355 | 0.84 | NPC1 (0.42) | MAPK1HPGDDYRK1ALMNARAB9A | |
| SCHEMBL10252659 | 0.84 | GRIK2 (0.54) | GRIK2GRIK1KDM4EALDH1A1MAPK1 | |
| SCHEMBL13152272 | 0.82 | GRIK2 (0.39) | GRIK2GRIK1KDM4EALDH1A1MAPK1 | |
| SCHEMBL12109159 | 0.82 | GRIK2 (0.39) | GRIK2GRIK1KDM4EALDH1A1MAPK1 | |
| SCHEMBL10252484 | 0.82 | PLK4 (0.40) | KDM4EMAPK1DYRK1ARAB9ANPC1 | |
| SCHEMBL10249587 | 0.82 | HRH3 (0.46) | ALDH1A1MAPK1HPGDRAB9ANPC1 | |
| SCHEMBL10249762 | 0.82 | HRH3 (0.49) | MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118009-A1 | HCV INHIBITOR AND THERAPEUTIC AGENT COMBINATIONS | PTC THERAPEUTICS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |