Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK2 | Q13002 | 3/20 | 0.49 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.44 |
| ▸ | HASPIN | Q8TF76 | 6/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 2/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13152059 | 0.91 | GRIK2 (0.49) | GRIK2GRIK1KDM4EALDH1A1MAPK1 | |
| SCHEMBL13152064 | 0.91 | GRIK2 (0.49) | GRIK2GRIK1KDM4EALDH1A1MAPK1 | |
| SCHEMBL13152426 | 0.89 | GRIK2 (0.48) | GRIK2GRIK1KDM4EALDH1A1MAPK1 | |
| SCHEMBL13152570 | 0.89 | GRIK2 (0.52) | GRIK2GRIK1KDM4EALDH1A1MAPK1 | |
| SCHEMBL13152544 | 0.89 | GRIK2 (0.60) | GRIK2GRIK1KDM4EALDH1A1MAPK1 | |
| SCHEMBL13152441 | 0.87 | GRIK2 (0.46) | GRIK2GRIK1KDM4EALDH1A1MAPK1 | |
| SCHEMBL13152222 | 0.86 | GRIK2 (0.46) | GRIK2GRIK1KDM4EALDH1A1MAPK1 | |
| SCHEMBL10252659 | 0.86 | GRIK2 (0.54) | GRIK2GRIK1KDM4EALDH1A1MAPK1 | |
| SCHEMBL979769 | 0.84 | GRIK2 (0.48) | GRIK2GRIK1KDM4EALDH1A1MAPK1 | |
| SCHEMBL13152724 | 0.84 | GRIK2 (0.60) | GRIK2GRIK1KDM4EALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118009-A1 | HCV INHIBITOR AND THERAPEUTIC AGENT COMBINATIONS | PTC THERAPEUTICS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |