Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.40 |
| ▸ | IKBKB | O14920 | 5/20 | 0.39 |
| ▸ | DKK1 | O94907 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 2/20 | 0.39 |
| ▸ | IKBKG | Q9Y6K9 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 3/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12423145 | 0.83 | SYK (0.57) | SYKIKBKBDKK1GSK3BCHUK | |
| SCHEMBL12423159 | 0.76 | IKBKB (0.49) | SYKIKBKBDKK1GSK3BCDK4 | |
| SCHEMBL12423187 | 0.75 | CLK1 (0.67) | SYKGSK3BCDK4CDK2CLK1 | |
| SCHEMBL12423190 | 0.75 | SYK (0.58) | SYKIKBKBDKK1GSK3BJAK2 | |
| SCHEMBL12423172 | 0.75 | PIK3CG (0.52) | SYKIKBKBCDK4CDK2CDK1 | |
| SCHEMBL12423171 | 0.74 | IKBKB (0.55) | SYKIKBKBDKK1GSK3BCDK4 | |
| SCHEMBL12423166 | 0.74 | SYK (0.58) | SYKIKBKBDKK1GSK3BCHUK | |
| SCHEMBL12423191 | 0.74 | MEN1 (0.55) | SYKIKBKBDKK1GSK3BCHUK | |
| SCHEMBL12423169 | 0.74 | CDK2 (0.53) | SYKIKBKBDKK1GSK3BJAK2 | |
| SCHEMBL12423148 | 0.73 | ZAP70 (0.61) | SYKIKBKBDKK1GSK3BCDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803806-B2 | Pyrimidinyl-thiophene kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2010-09-28 | — | — | US | disclosed |
| US-7803806-B2 | Pyrimidinyl-thiophene kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2010-09-28 | — | — | US | disclosed |