Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 20/20 | 0.78 |
| ▸ | JAK2 | O60674 | 1/20 | 0.67 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.67 |
| ▸ | IGF1R | P08069 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | AKT1 | P31749 | 1/20 | 0.67 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.67 |
| ▸ | NEK2 | P51955 | 1/20 | 0.67 |
| ▸ | STK3 | Q13188 | 1/20 | 0.67 |
| ▸ | CAMK4 | Q16566 | 1/20 | 0.67 |
| ▸ | TSSK2 | Q96PF2 | 1/20 | 0.67 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14216580 | 0.92 | CHEK1 (0.67) | CHEK1JAK2ROCK2IGF1RMAPK1 | |
| SCHEMBL13156187 | 0.89 | CHEK1 (0.74) | CHEK1JAK2ROCK2IGF1RMAPK1 | |
| SCHEMBL13156217 | 0.88 | CHEK1 (1.00) | CHEK1JAK2ROCK2IGF1RMAPK1 | |
| SCHEMBL13028168 | 0.88 | CHEK1 (0.59) | CHEK1JAK2ROCK2IGF1RMAPK1 | |
| SCHEMBL13156185 | 0.87 | CHEK1 (0.78) | CHEK1JAK2ROCK2IGF1RMAPK1 | |
| SCHEMBL11924203 | 0.86 | CHEK1 (0.58) | CHEK1JAK2ROCK2IGF1RMAPK1 | |
| SCHEMBL13156183 | 0.84 | CHEK1 (0.81) | CHEK1JAK2ROCK2IGF1RMAPK1 | |
| SCHEMBL13156213 | 0.84 | CHEK1 (0.86) | CHEK1JAK2ROCK2IGF1RMAPK1 | |
| SCHEMBL11923918 | 0.83 | CHEK1 (0.54) | CHEK1JAK2ROCK2IGF1RMAPK1 | |
| SCHEMBL13156192 | 0.82 | CHEK1 (0.81) | CHEK1JAK2ROCK2IGF1RMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078004-B1 | 2-AMINOTHIAZOLE-4-CARBOXYLIC AMIDES AS PROTEIN KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-02-25 | — | — | EP | disclosed |
| US-8318735-B2 | 2-aminothiazole-4-carboxylic amides as protein kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-11-27 | — | — | US | disclosed |
| US-8318735-B2 | 2-aminothiazole-4-carboxylic amides as protein kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-11-27 | — | — | US | disclosed |
| US-20100249030-A1 | ANTI-MITOTIC AGENT AND AURORA KINASE INHIBITOR COMBINATION AS ANTI-CANCER TREATMENT | SCHERING CORPORATION | 2010-09-30 | — | — | US | disclosed |
| US-20100130465-A1 | 2-AMINOTHIAZOLE-4-CARBOXYLIC AMIDES AS PROTEIN KINASE INHIBITORS | MERCK SHARP & DOHME LLC | 2010-05-27 | — | — | US | disclosed |
| US-20100130465-A1 | 2-AMINOTHIAZOLE-4-CARBOXYLIC AMIDES AS PROTEIN KINASE INHIBITORS | MERCK SHARP & DOHME LLC | 2010-05-27 | — | — | US | disclosed |
| WO-2009017701-A2 | ANTI-MITOTIC AGENT AND AURORA KINASE INHIBITOR COMBINATION AS ANTI-CANCER TREATMENT | SCHERING CORPORATION (US) | 2009-02-05 | — | — | WO | disclosed |
| WO-2008054749-A1 | 2-AMINOTHIAZOLE-4-CARBOXYLIC AMIDES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249030-A1 | ANTI-MITOTIC AGENT AND AURORA KINASE INHIBITOR COMBINATION AS ANTI-CANCER TREATMENT | AURKC, AURKA, AURKB | CHEK1 61/4885JAK2 2406/4885ROCK2 390/4885 |
| US-20100130465-A1 | 2-AMINOTHIAZOLE-4-CARBOXYLIC AMIDES AS PROTEIN KINASE INHIBITORS | MAPK15, CDK15, MAP3K15 | CHEK1 395/4885JAK2 42/4885ROCK2 794/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.