Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 5/20 | 0.48 |
| ▸ | HRH1 | P35367 | 2/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13157387 | 0.85 | SLC6A4 (0.40) | SLC6A4SLC6A2CYP2D6KCNH2KDM4E | |
| SCHEMBL13157416 | 0.83 | SLC6A4 (0.49) | SLC6A4SLC6A2CYP2D6KCNH2HTR2A | |
| SCHEMBL2301865 | 0.78 | SLC6A4 (0.60) | SLC6A4SLC6A2CYP2D6KCNH2HTR2A | |
| SCHEMBL13157426 | 0.77 | SLC6A4 (0.53) | SLC6A4SLC6A2CYP2D6KCNH2HTR2A | |
| SCHEMBL13157395 | 0.77 | SLC6A4 (0.56) | SLC6A4SLC6A2CYP2D6KCNH2HTR2A | |
| SCHEMBL2075086 | 0.77 | SLC6A4 (0.69) | SLC6A4SLC6A2CYP2D6KCNH2HTR2A | |
| SCHEMBL2073872 | 0.76 | SLC6A4 (0.67) | SLC6A4SLC6A2CYP2D6KCNH2HTR2A | |
| SCHEMBL2069976 | 0.76 | SLC6A4 (0.67) | SLC6A4SLC6A2CYP2D6KCNH2HTR2A | |
| SCHEMBL2075066 | 0.76 | SLC6A4 (0.67) | SLC6A4SLC6A2CYP2D6KCNH2HTR2A | |
| SCHEMBL2071842 | 0.76 | SLC6A4 (0.67) | SLC6A4SLC6A2CYP2D6KCNH2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803830-B2 | 3-amino-1-arylpropyl indoles and AZA-substituted indoles and uses thereof | ROCHE PALO ALTO LLC (US) | 2010-09-28 | — | — | US | disclosed |
| US-20090099236-A1 | 3-Amino-1-arylpropyl indoles and AZA-substituted indoles and uses thereof | ROCHE PALO ALTO LLC | 2009-04-16 | — | — | US | disclosed |
| US-7446118-B2 | 3-amino-1-arylpropyl indoles and aza-substituted indoles and uses thereof | ROCHE PALO ALTO LLC (US) | 2008-11-04 | — | — | US | disclosed |
| US-20070123527-A1 | 3-Amino-1-arylpropyl indoles and aza-substituted indoles and uses thereof | ROCHE PALO ALTO LLC | 2007-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123527-A1 | 3-Amino-1-arylpropyl indoles and aza-substituted indoles and uses thereof | IDO1, RB1, AHR | SLC6A4 597/4885SLC6A2 1181/4885CYP2D6 27/4885 |
| US-20090099236-A1 | 3-Amino-1-arylpropyl indoles and AZA-substituted indoles and uses thereof | IDO1, RB1, AHR | SLC6A4 597/4885SLC6A2 1181/4885CYP2D6 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.